AccScience Publishing / ITPS / Volume 6 / Issue 2 / DOI: 10.36922/itps.417
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REVIEW

Precision medicine in neurosurgery: The evolving role of theranostics

Drashti Patel1 ,  Andrew Nguyen1 ,  Chance Fleeting1 ,  Anjali B. Patel1 ,  Mohammed Mumtaz1 ,  Brandon Lucke-Wold1 *
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1 Department of Neurosurgery, University of Florida, College of Medicine, Gainesville, Florida, USA
INNOSC Theranostics and Pharmacological Sciences 2023, 6(2), 417 https://doi.org/10.36922/itps.417
Submitted: 9 April 2023 | Accepted: 13 July 2023 | Published: 3 August 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
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Abstract

Theranostics in neurosurgery is a rapidly advancing field of precision medicine that combines diagnostic and therapeutic modalities to optimize patient outcomes. This approach has the potential to provide real-time feedback during therapy and diagnose a condition while simultaneously providing treatment. One such form of theranostics is focused ultrasound, which has been found to be effective in inducing neuroablation and neuromodulation and improving the efficacy of chemotherapy drugs by disrupting the blood–brain barrier. Targeted radionuclide therapy, which pairs positron emission tomography tracers with therapeutic effects and imaging modalities, is another promising form of theranostics for neurosurgery. Automated pathology analysis is yet another form of theranostics that can provide real-time feedback during the surgical resection of tumors. Electrical stimulation has also shown promise in optimizing therapies for patients with cerebral palsy. Overall, theranostics is a cost-effective way to optimize medical care for patients in neurosurgery. It is a relatively new field, but the advancements made so far show great promise for improving patient outcomes.

Keywords
Focused ultrasound
Radiopharmaceuticals
Electrical stimulation
Cerebral palsy
Intraoperative consultation
Automated pathology analysis
Funding
None.
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Conflict of interest
The authors declare that they have no conflicts of interest.
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